The way to make nothing of our life is to be very careful of it, to hold it back from perilous duty, from costly service, to save it from the waste of self-denial and sacrifice. The way make our life an eternal success is to do with it what Jesus did with his--present it a living sacrifice to God, to be used wholly for him. Men said he threw his life away, and so it certainly seemed up to the morning of his resurrection. But no one would say that now of Christ. His was the throwing away of life which led to its glorifying. In no other way can we make anything worthy and eternal of our life. Saving is losing. It is losing it in devotion to Christ and his service that saves a life for heavenly honour and glory.
Matthew 10:38-39 (also Luke 9:24): And he that taketh not his cross, and followeth after me, is not worthy of me. He that findeth his life shall lose it: and he that loseth his life for my sake shall find it. (KJV)
John 12:24-25: Verily, verily, I say unto you, Except a corn of wheat fall into the ground and die, it abideth alone: but if it die, it bringeth forth much fruit. He that loveth his life shall lose it; and he that hateth his life in this world shall keep it unto life eternal. (KJV)